What is Hyperimmunised Plasma?

At Veterinary Immunogenics, we take great care and pride in providing veterinary biologic products that help animals live longer, healthier lives. Veterinary Immunogenics was started out of a passion for horses. From our facility in beautiful Penrith, UK we collect and process HYPERMUNE® and HYPERMUNE-RE® hyperimmunised plasma for the treatment of a variety of equine conditions.

What is Hyperimmunised Plasma?

Plasma is the liquid, cell-free component of mammalian blood. Hyperimmunised plasma contains an increased level of antibodies (immunoglobulin) compared to normal plasma. These increased antibodies have been shown to provide greater protection from infections, as well as promote faster healing and recovery times. Plasma supports the animal’s natural immune system, so there are fewer side effects and drug interactions.

Hyperimmunised equine plasma is used for the prevention and treatment of conditions such as Failure of Passive Transfer (FPT) in foals and Rhodococcus equi infections. Additionally, it can shorten recovery times from other diseases and injuries.

Veterinary Immunogenics’ 100% traceable, single-source, cell-free plasma is collected exclusively from our donor animals. All our products are rigorously tested and produced under the regulations of the UK Veterinary Medicines Directorate and Home Office licenses.


Hyperimmunised plasma can only come from donor animals who adhere to a regimen of testing, vaccinations, and monitoring. Before being accepted into the closed donor group, animals are quarantined and screened for suitability as plasma and red cell donors by independent laboratories.

Our equine donors reside at our Penrith facility and are screened, tested, and hyperimmunised for specific diseases, such as Rhodococcus equi. Every Veterinary Immunogenics donor animal is tended to by veterinary professionals who love what they do.

Collection Process

Plasma is collected by specially trained pheresis technicians who know and care for each donor animal. Veterinary Immunogenics’ plasma products are  quality control tested immediately after collection and are only sold once the product meets all specifications.

Benefits and Results

Hyperimmunised plasma has shown efficacy for a variety of illnesses and injuries. In horses, hyperimmunised plasma has several applications. Since foals are born with few antibodies, they need the benefits of IgG provided by the mother’s colostrum. When antibodies cannot be passed through the colostrum, the foal can suffer from Failure of Passive Transfer (FPT), which can be fatal. HYPERMUNE provides the necessary IgG antibodies to help every foal reach its full potential.

Complete Failure of Passive Transfer in foals is defined as an IgG level of less than 400 mg/dL, and Partial Failure of Passive Transfer is an IgG level between 400-800 mg/dL, 24 hours after birth. Administering one unit of plasma at birth can provide the foal with the antibodies it needs, giving it the best start in life.

In addition to FPT treatment in foals, HYPERMUNE-RE can be used to prevent Rhodococcus equi and other serious infections.

For additional information on HYPERMUNE and HYPERMUNE-RE and their life-saving potential, please visit our research page.